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Besondere Vorsicht gilt theoretisch bei einer Vorgeschichte von Krebserkrankungen , da IGF-1 ein zellwachstumsfrderndes Signal darstellt

One open-label randomized trial without a placebo control group compared PPS to CyA and reported that CyA patients experienced a statistically significantly higher rate (83%) of clinically significant improvement compared to PPS patients (21%)

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A comprehensive review of seven studies with well over 1.5 million participants found a 26% increased risk of accelerating CKD progression with habitual use of high-dose NSAIDs (Nderitu 2013)